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Head and Neck Surgery

p16+ (HPV+) OPSCC: A Surgical Approach to Management

Sunday, October 1, 2023
1:00 PM - 2:00 PM East Coast USA Time
Location: Ballroom C2

    Moderator(s)

  • CW

    C. Burton Wood, MD

    Assistant Professor
    UTHSC
    Memphis, TN, United States

    • Panelist(s)

  • Sid V. Puram, MD PHD

    Chief, Head and Neck Surgery
    Washington University - St. Louis
    St Louis, MO, United States

  • RJ

    Ryan S. Jackson, MD

    Associate Professor
    Washington University School of Medicine
    St. Louis, MO, United States

  • Wade L. Thorstad, MD

    Professor
    Washington University School of Medicine in St. Louis
    St. Louis, MO, United States

Disclosure(s):
C. Burton Wood, MD: No relevant relationships to disclose.
Ryan S. Jackson, MD: No relevant relationships to disclose.
Wade L. Thorstad, MD: No relevant relationships to disclose.
PROGRAM DESCRIPTION: This panel serves to provide a focused review of the current guidelines based on NCCN recommendations for management of HPV+ oropharyngeal cancer. Using a case-based discussion format, the panelists highlight major controversies relating to the management of these patients based on the most up to date research. The topic is timely and relevant, as there are new studies enrolling patients and entering into the published literature with great frequency, some of which are supportive of primarily surgical approaches for this patient population and others that suggest surgery is only useful in limited settings. Additionally, given the anticipated continued increase in the prevalence of HPV mediated oropharynx cancers, Otolaryngologists will continue seeing more and more of these patients in their practices. While the panel highlights treatment strategies that are implemented at major cancer centers, it also provides comprehensive otolaryngologists with a better sense of appropriate work-up for these patients, when referral to tertiary care centers is necessary, and why close discussion with other multi-disciplinary providers is crucial. To that end, one of the involved panelists is a Radiation Oncologist who provides good insight into the thought processes of our Radiation Oncology colleagues when developing treatment plans for these patients. Further, the inclusion of a non-surgeon on this panel leads to a more insightful discussion on the merits of non-surgical treatment strategies versus primarily surgical treatment paradigms.

OUTCOME OBJECTIVE 1: Understand the treatment options based on NCCN guidelines for p16+ OPSCC.

OUTCOME OBJECTIVE 2: Describe the rationale and approach for surgically focused management of p16+ OPSCC.

OUTCOME OBJECTIVE 3: Appreciate the major DOs and DONTs of p16+ OPSCC treatment, including the role of adjuvant therapy.

BACKGROUND STATEMENT: The general Otolaryngology community needs continual discussion on the present literature and current treatment strategies for HPV mediated oropharynx cancers given the continued increase in prevalence of this disease process as well as the varying treatment strategies that are employed.