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Comprehensive Otolaryngology

(224) Hearing loss and HRQoL in sickle cell disease and traits

Monday, October 2, 2023
2:45 PM – 3:45 PM East Coast USA Time
Has Audio

    Presenting Author(s)

  • Titus S. Ibekwe, MD, FWACS

    Professor of Otorhinolaryngology University of Abuja Nigeria & PhD Audiology student UCT CapeTown
    University of Abuja College of Health Sciences
    Abuja, Federal Capital Territory, Nigeria

    • Co-Author(s)

  • cR

    christine Rogers, PhD

    Clinical Audiologist and Senior Lecturer, Department of Health and Rehabilitation Sciences Universi
    University of Cape Town
    Cape Town, Western Cape, South Africa

    • Senior Author(s)

  • lR

    lebogang Ramma, PhD

    Lebogang Ramma is Professor of Audiology, Department of Health and Rehabilitation Sciences Universi
    University of Cape Town
    Cape Town, Western Cape, South Africa

Disclosure(s):
Titus S. Ibekwe, MD, FWACS: No relevant relationships to disclose.


Introduction: Sickle cell disease(SCD) and traits(SCT) are genetic disorders with relatively high prevalence among sub-Saharan Africans and African Americans. Hearing loss and overall-poor health status have been associated with SCD but no consensus on SCT. Hence, the aim of this study was to assess and characterize the hearing loss and HRQoL in SCD and SCT.

Methods: A comparative cross-sectional study conducted between 2nd Feb 2022 and 30th June 2023 on cohorts and control groups for hearing and assessment of HRQoL in SCD and SCT at University of Abuja Teaching Hospital, Nigeria. The audiometric tests and WHOADS2 questionnaire/instruments assessed for hearing loss and the HRQol respectively. Statistical analyses were done with Statistical Analysis System (SAS 9.4). Study was fully registered (HREC REF 228/2022) and (UATH/HREC/PR/2020/08/007 for PhD thesis by UCT(Capetown) and University of Abuja Nigeria respectively.

Results: A total of 212 participants(cohorts and tests), age range 6months -55 years (Means 15.1±9.9 and 15.6±12.9) featured in the research. Prevalence of hearing loss 28% 95%CI[18.3-35.3), (SNHL, mainly moderate to severe) was significant in SCD but not SCT. The occupation/Educational levels of the mothers of both SCD and SCT participants (P=0.016) and the duration of diagnosis of SCD genotype for (P < 0.001) were strong demographic factors that influenced the health status. The HRQoL study showed that Cognition, mobility, work –ability and social life were significantly impaired among SCD; whereas only work-ability and relationship were affected in SCT.

Conclusions: Hearing loss is significantly associated with Sickle cell disease, whereas the Health Related qualities of lives are depressed in both SCDs and SCTs with higher impacts on the SCDS. Awareness and early diagnosis appears to be strong positive predictive factors.