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Rhinology/Allergy

(233) High Intensity Focused Ultrasound Stimulators for Turbinate Hypertrophy

Monday, October 2, 2023
2:45 PM – 3:45 PM East Coast USA Time

    Presenting Author(s)

  • SC

    Sung-Woo Cho, MD

    MD
    Seoul National University Bundang Hospital
    Seongnam, Kyonggi-do, Republic of Korea

    • Co-Author(s)

  • SC

    Sung Chan Cho, N/A

    KORUST Company Limited
    Anyang, KOR

  • DH

    Doo Hee Han, MD

    Professor
    Seoul National Universuty Hospital
    Seoul, Seoul-t'ukpyolsi, KOR

    • Senior Author(s)

  • Chae-Seo Rhee, MD

    Professor
    Seoul National Universuty College of Medicine
    Seoul, Republic of Korea

Disclosure(s):
Sung-Woo Cho, MD: No relevant relationships to disclose.
Chae-Seo Rhee, MD: No relevant relationships to disclose.


Introduction: High-intensity focused ultrasound (HIFU) ablation induced histologic change and volume reduction of inferior turbinate in animal study. In this study we tried to evaluate weather HIFU could symptomatically improve nasal obstruction in patients with inferior turbinate hypertrophy (ITH).

Methods: A prospective, randomized, double-blinded clinical trial was performed. 16 patients with ITH complaining severe nasal congestion (VAS ≥ 4) were recruited. 7 patients in test group underwent IT surgery with HIFU system(‘RHINOS’), and 9 in control group underwent conventional high frequency coblator surgery. To evaluate subjective and objective improvement, nasal congestion symptom score (10 point VAS scale), NOSE scale, and acoustic rhinometry was evaluated at base line, 1 week, 4 weeks, and 12 weeks. In addition, satisfaction with the procedure (10 point VAS scale) was compared at 12 weeks, respectively. Finally, the safety and stability of procedure was compared through evaluation on degree of IT edema, discharge, and crust formation using endoscopic exam during the study period

Results: Sixteen patients initially enrolled the study, 2 had been dropped out. Both groups showed symptom improvement (VAS scale) and NOSE scale compared to baseline and there was no significant difference in variation amount between groups. There was no significant change in mean minimal cross-sectional area changed cross sectional area in both groups at 12 weeks after procedure.
There was no meaningful difference in procedure satisfaction after 12 weeks between groups.
IT hypertrophies were significantly decreased in both groups at 12 weeks, with no significant between group difference. There was no significant difference in discharge or crusting at 12 weeks between groups. However, discharge and crusting in the test group was significantly smaller in both nasal cavity than that of control group at 1 and 4 weeks after procedure.

Conclusions: HIFU system seems to have benefits in minimizing procedure related morbidity in office-based procedure for turbinoplasty. This warrants a large prospective clinical trial in the future.