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Pediatric Otolaryngology

(353) OSA in Children with and Without Sickle Cell Disease

Monday, October 2, 2023
2:45 PM – 3:45 PM East Coast USA Time
Has Audio

    Presenting Author(s)

  • Derek Sheen, MD

    PGY4
    University of Texas Southwestern Medical School
    Dallas, Texas, United States

    • Co-Author(s)

  • W. Craig Kemper, MD

    Resident
    Baylor College of Medicine
    Houston, Texas, United States

  • Helene K. Dabbous, MD

    Pediatric Otolaryngology Fellow
    University of Texas Southwestern Medical School
    Beirut, Beyrouth, Lebanon

    • Co-Author(s)

  • CA

    Claire A. Abijay, Other

    University of Texas Southwestern Medical Center, USA

  • Romaine F. Johnson, MD, MPH

    Professor
    Univ of Texas Southwestern Med Ctr
    DALLAS, TX, United States

  • Ron B. Mitchell, MD

    Vice-Chairman, Professor
    University of Texas Southwestern Medical Center, Department of Otolaryngology
    Dallas, Texas, United States

Disclosure(s):
Helene K. Dabbous, MD: No relevant relationships to disclose.
W. Craig Kemper, MD: No relevant relationships to disclose.
Romaine F. Johnson, MD, MPH: No relevant relationships to disclose.
Ron B. Mitchell, MD: No relevant relationships to disclose.


Introduction: To identify predictors of Pediatric Obstructive Sleep Apnea (OSA), severe OSA, and residual OSA in children with Sickle Cell Disease (SCD) and without SCD using a case-control study design.

Methods: A total of 276 children were included in the study, 187 without SCD and 89 with SCD. Data collected on patient demographics, polysomnography data, and surgical data was analyzed to identify predictors of OSA, severe OSA, and residual OSA.

Results: The study found that children with SCD had a lower odds of severe OSA (AHI > 10) compared to those without SCD (odds ratio 0.33, 95% CI 0.19-0.57, p< 0.001). Tonsil hypertrophy was found to be a predictor of severe OSA in the preoperative group (odds ratio 1.91, 95% CI 1.13-3.24, p=0.016). Female gender was found to be a predictor of severe OSA in the postoperative group (odds ratio 3.03, 95% CI 1.29-7.08, p=0.011). No predictors were found for residual OSA (AHI < 5) after treatment.

Conclusions: This study found that children with SCD have a lower odds of severe OSA preoperatively, tonsil hypertrophy is a predictor of severe OSA preoperatively and female gender is a predictor of severe OSA postoperatively. It also found no predictors for residual OSA after treatment. These findings can help identify children with SCD at higher risk for OSA and predict which children may have a higher risk of complications from surgery.